It is contraindicated in patients with a known allergy to penicillins, sulbactam, cefoperazone, or any of the cephalosporins.
Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving beta-lactam or cephalosporin therapy. These reactions are more apt to occur in individuals with a history of hypersensitivity reactions to multiple allergens. If an allergic reaction occurs, the drug should be discontinued and the appropriate therapy instituted.
As with other antibiotics, overgrowth of non-susceptible organisms may occur during the prolonged use of CEFOZONE. It has not been extensively studied in premature infants or neonates. Therefore, in treating premature infants and neonates, the potential benefits and possible risks involved should be considered before instituting therapy.
A reaction characterized by flushing, sweating, headache and tachycardia has been reported when alcohol was ingested during and as late as the fifth day after Cefoperazone administration. A similar reaction has been reported with certain other cephalosporins and patients should be cautioned concerning ingestion of alcoholic beverages in conjunction with administration of CEFOZONE. For patients requiring artificial feeding orally or parenterally, solutions containing ethanol should be avoided.
In severe hepatic dysfunction, therapeutic concentrations of Cefoperazone are obtained in the bile and only a 2-to 4-fold increase in the half-life is seen. Dose modification may be necessary in case of severe biliary obstruction, severe hepatic disease or in case of renal dysfunction coexistent with either of those conditions.
There are no adequate and well-conTolled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
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Cefozon is used to treat bacterial infection of the respiratory tract, the abdomen and abdominal wall (peritonitis), the urinary tract, the female genital tract (endometritis, pelvic inflammatory disease), the blood (septicemia), and the skin and soft tissues.
Cefoperazone Sodium Injection use, safety information, warnings and side effects, indications and usage, adverse reactions and clinical pharmacology.
Cefoperazone Sulbactam Injection is used for Intra abdominal infections, Bacterial infections, Urinary tract infection, Skin and soft tissue infection, Infections of the respiratory tract, Endometritis, Surgical infections, Bacterial infection, Gynecological infections, Respiratory tract infections and other conditions. Cefoperazone Sulbactam Injection may also be used for purposes not listed in this medication guide.