Generic Name

Sulbactam & Cefoperazone For Injection

Brand Name

CEFOZONE®

Dosage Form

POWDER FOR PREPARATION OF INJECTION SOLUTION

Strength and Dosage

1g

Product Description

The combination of Sulbactum and Cefoperazone is active against all organisms sensitive to cefoperazone. In addition, it demonstrates synergistic activity (up to 4-fold reduction in the minimum inhibitory concentrations for the combination versus those for each component) in a variety of organisms.

Cefoperazone Sodium 1gm

About Cefoperazone Sodium A third generation cephalosporin antibiotic, Parenteral antibiotic. Mechanism of Action of Cefoperazone Sodium Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefoperazone. It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis Pharmacokinets of Cefoperazone Sodium Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: It is not significantly metabolized inside the body. Excretion: Excreted mainly through bile & a small portion is excreted in urine. A small amount is seen in breast milk.

Indications for Cefoperazone Sodium + Sulbactam SodiumIt is a combination of third generation Cephalosporins Cefperazone sodium and Beta-lactamase inhibitor Sulbactam.

1.Pharyngitis

2.Tonsillitis

3.Pneumonia

4.Bronchitis

5.Other respiratory tract infections

6.Septicemia

7.Meningitis

8.Urinogenital tract infections

9.Bone & Joint infections

10.Gonorrhea

11.Endometritis

12.Skin & Soft tissue infections

13.Pelvic inflammatory diseases

14.Intra abdominal infections

Interactions for Cefoperazone Sodium + Sulbactam Sodium N/A Typical Dosage for Cefoperazone Sodium + Sulbactam Sodium

Adults:

1 to 2 gm I.M. or I.V. twice daily

In severe infections:

3 to 4 gm I.M. or I.V. thrice daily

Maximum adult dose: 8gm/day.

Children:

40 to 80 mg / kg / day two times daily to four times daily

Maximum child dose: 160 mg / kg / daily

Onset of Action for Cefoperazone Sodium Sudden Duration of Action for Cefoperazone Sodium 12 hoursHalf Life of Cefoperazone Sodium 2 hours

Side Effects of Cefoperazone Sodium

1. Pain after I.M. injection & thrombophlebitis after I.V. injection.

2. Rashes & allergic manifestation

3. Super infection

4. Pseudo membranous colitis

5. Nausea

6. Vomiting

7. Diarrhea

8. Elevated liver enzymes

9. Neutropenia

10. Hypoprothrombinemia

Contra-indications of Cefoperazone Sodium

1. Hypersensitivity to cephalosporins

2. Pseudo membranous colitis

Special Precautions while taking Cefoperazone Sodium

1. Renal impairment

2. Hepatic impairment

3. Patient allergic to penicillins

4. Neuromuscular disorders

5. Along with other nephrotoxic drugs

Pregnancy Related Information

Use with caution.Old Age Related Information May be used.Breast Feeding Related Information Use with caution.Children Related Information Use with caution.

Neonates: contraindicatedIndications for Cefoperazone Sodium

1. Meningitis

2. Biliary infections

3. Septicemia

4. Infections in immunocompromised patients

5. Urinary tract &genital tract infections

6. Surgical prophylaxis

7. Skin & soft tissue infections

8. Bone & Joint infections

9. Gonorrhea,

10. Peritonitis.

Interactions for Cefoperazone SodiumAlcohol: Disulfiram like reaction up to 72 hours after cefoperazone intake.

Aminoglycosides (Gentamycin, Tobramycin): Nephrotoxicity of aminoglycosides potentiated.

Oral anticoagulants: Hypothrombinemic effect potentiated, bleeding complications may occur.

Bacteriostatic agents like Chloramphenicol: Decreases efficacy of Cefoperazone sodium.

Probenecid: Slows tubular excretion and this enhances efficacy.

Frusemide & Ethacrynic Acid: Potentiate nephrotoxicity of Cefoperazone Sodium.

Lab. Test: Urine Glucose: False positive with Benedicts solution and Fehlings solution.

Direct Coombs Test: False positive.

Urinary 17-Ketosteroid values: Falsely elevated values.

Typical Dosage for Cefoperazone Sodium Adults: 1g to 2gm I.M. or I.V. two times daily to three times daily.

In severe infections: 12gm/day in two to four divided doses

Children: 50 to 200 mg/kg/day I.M or I.V. two times daily

In meningitis child dosage: Up to 300mg/kg/day

Maximum adult dose: Up to 12gm/day

Maximum child dose: 300mg/kg/day

Schedule of Cefoperazone Sodium H 1

Storage Requirements for Cefoperazone Sodium

Store in a refrigerator & away from light.Effects of Missed Dosage of Cefoperazone SodiumTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.

Effects of Overdose of Cefoperazone Sodium

Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Hypoprothrombinemia may also occur. Treatment includes removal of drug from the body by dialysis, administration of vitamin K or blood products & supportive measures